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Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity faster CD4+ T cell decline and increased immune activation during acute infection

机译：具有多种HIV-1创始体变体的感染与病毒复制能力较低CD4 + T细胞下降并增加急性感染期间的免疫激活增加

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期刊名称 PLoS Pathogens
作者
Gladys N. Macharia; Ling Yue; Ecco Staller; Dario Dilernia; Daniel Wilkins; Heeyah Song; Edward McGowan; Deborah King; Pat Fast; Nesrina Imami; Matthew A. Price; Eduard J. Sanders; Eric Hunter; Jill Gilmour; Richard A. Koup; Ronald Swanstrom; Richard A. Koup; Ronald Swanstrom; Richard A. Koup; Ronald Swanstrom;
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年(卷),期 2020(16),9
年度 2020
页码 e1008853
总页数 22
原文格式 PDF
正文语种
中图分类微生物学;寄生动物、寄生虫学;医学寄生虫学;人体病毒学（致病病毒）;病毒（滤过性病毒）;
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专利

1. Serum immune activation markers are persistently increased in patients with HIV infection after 6 years of antiretroviral therapy despite suppression of viral replication and reconstitution of CD4+ T cells. [J] . French MA, King MS, Tschampa JM The Journal of Infectious Diseases . 2009,第8期

机译：经过6年的抗逆转录病毒治疗后，HIV感染患者的血清免疫激活标记物持续增加，尽管抑制了病毒复制和CD4 + T细胞的重建。
2. Serum Immune Activation Markers Are Persistently Increased in Patients with HIV Infection after 6 Years of Antiretroviral Therapy despite Suppression of Viral Replication and Reconstitution of CD4+ T Cells [J] . Martyn A. French1 Martin S. King2 Jean M. Tschampa2 Barbara A. da Silva2 and Alan L. Landay3 Journal of Infectious Diseases . 2009,第8期

机译：尽管抑制了病毒复制和CD4 + T细胞的重建，抗病毒治疗6年后HIV感染患者的血清免疫激活标记仍持续升高
3. HIV-1 Vpr Accelerates Viral Replication during Acute Infection by Exploitation of Proliferating CD4+ T Cells In Vivo [J] . Kei Sato, Naoko Misawa, Shingo Iwami, PLoS Pathogens . 2013,第12期

机译：HIV-1 VPR通过在体内激活CD4 + T细胞来加速急性感染期间的病毒复制
4. Ig levels and B cell differentiative capacity predict the risk of acute infections in CVID [C] . Quinti I., Guerra A., Visentini M., European Congress of Immunology . 2009

机译：IG水平和B细胞分化能力预测CVID中急性感染的风险
5. Humoral and cellular immune responses in RNA viral infections: Immunogenicity of HIV-1, HCV and SARS-CoV candidate vaccines in animal models. [D] . Azizi, Ali. 2006

机译：RNA病毒感染中的体液和细胞免疫应答：HIV-1，HCV和SARS-CoV候选疫苗在动物模型中的免疫原性。
6. HIV-1 infections with multiple founders are associated with higher viral loads than infections with single founders [O] . Holly Janes, Joshua T. Herbeck, Sodsai Tovanabutra, -1

机译：具有多个创建者的HIV-1感染比具有单个创建者的感染具有更高的病毒载量
7. Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity, faster CD4+ T cell decline and increased immune activation during acute infection [O] . Gladys N. Macharia, Ling Yue, Ecco Staller, 2020

机译：具有多种HIV-1创始体变体的感染与病毒复制能力较低，CD4 + T细胞下降并增加急性感染期间的免疫激活增加

Infection with multiple HIV-1 founder variants is associated with lower viral replicative capacity faster CD4+ T cell decline and increased immune activation during acute infection

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