首页> 美国卫生研究院文献>Cell Transplantation >The Effect of Autologous Adipose Tissue–Derived Mesenchymal Stem Cells’ Therapy in the Treatment of Chronic Posttraumatic Spinal Cord Injury in a Domestic Ferret Patient
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The Effect of Autologous Adipose Tissue–Derived Mesenchymal Stem Cells’ Therapy in the Treatment of Chronic Posttraumatic Spinal Cord Injury in a Domestic Ferret Patient

机译:自体脂肪组织衍生的间充质干细胞疗法在国产雪兔患者治疗慢性创宫脊髓损伤中的影响

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摘要

Spinal cord injury (SCI) is considered as one of the most problematic neurological conditions requiring specialized clinical intervention. Taking into account that SCI is characterized by extensive loss of nerve cells, stem cell–based therapy seems to be a reasonable modern strategy to the treatment of SCI. The presented case report describes for the first time experimental treatment with the use of autologous adipose tissue–derived mesenchymal stem cells (ADSCs) of the chronic posttraumatic SCI in a domestic ferret patient with paresis of back legs. It should be noted that most reports in the available literature concern ADSC-based therapies for acute or subacute SCI treatment in other species. Application of ADSC-based therapy did not cause any adverse reactions and resulted in significant improvement of neurological and motor functions. Based on these outcomes, it may be concluded that this form of therapy is promising and may be potentially translated into clinical veterinary practice.
机译:脊髓损伤(SCI)被认为是需要专门的临床干预的最有问题的神经系统条件之一。考虑到SCI的特征在于丧失神经细胞的广泛丧失,基于干细胞的疗法似乎是治疗SCI的合理现代策略。所呈现的情况下报告描述了与使用自体脂肪组织来源的间充质干慢性创伤后SCI的细胞(脂肪干细胞),其与后腿轻瘫的国内鼬患者第一次实验性治疗。应该指出的是,可用文献中的大多数报告涉及基于ADSC的急性或亚急性SCI治疗在其他物种中的疗法。 ADSC的疗法的应用没有引起任何不良反应,导致神经系统和运动功能的显着改善。根据这些结果,可以得出结论,这种治疗的疗法是有前途的,可能被翻译成临床兽医实践。

著录项

  • 期刊名称 Cell Transplantation
  • 作者单位
  • 年(卷),期 2020(-1),-1
  • 年度 2020
  • 页码 -1
  • 总页数 10
  • 原文格式 PDF
  • 正文语种
  • 中图分类 移植;
  • 关键词

    机译:神经组织再生;抗炎作用;镇痛作用;paraplexis;干细胞的疗法;
  • 入库时间 2022-08-21 12:17:08

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