Inhibition of cytochrome P450 2B6 by Astragalus extract mixture HT042

摘要

UPLC–MS/MS analysis of bupropion hydroxylation by P450 2B6. Chromatograms of hydroxybupropion and bupropion in the multiple reaction mode (MRM). The positive ionization transitions of bupropion (m/z 240 > 184) and hydroxybupropion (m/z 256.1 > 238.1) were monitored