Abstract QS31: Calcium And Phosphate Ion Signaling Triggers Osteogenic Differentiation On Nanoparticulate Mineralized Collagen Glycosaminoglycan Scaffolds

摘要

Purpose: The instructive capabilities of extracellular matrix components in progenitor cell differentiation have recently generated significant interest in the development of bioinspired materials for regenerative applications. Previously, we demonstrated that a nanoparticulate mineralized collagen glycosaminoglycan material (MC-GAG) induced in vivo calvarial regeneration in the absence of exogenous growth factors or addition of exogenous progenitor cells via an autogenous activation of Smad1/5 in the canonical bone morphogenetic protein receptor (BMPR) signaling pathway in endogenous progenitor cells. We also demonstrated that this phenomenon was not found in non-mineralized collagen glycosaminoglycan (Col-GAG). In this work, we investigated the contribution of inorganic ion signaling as the trigger for osteogenic differentiation induced by MC-GAG.