Plasma Trimethylamine N-Oxide and Its Precursors: Population Epidemiology Parent–Child Concordance and Associations with Reported Dietary Intake in 11- to 12-Year-Old Children and Their Parents

摘要

Trimethylamine N-oxide (TMAO) is a microbiome- and diet-derived metabolite implicated in adverse cardiovascular outcomes. To date, studies of plasma TMAO concentrations have largely focused on individuals with metabolic disease. As such, data on TMAO concentrations in population settings and parent–child dyads are lacking.