Neonatal sevoflurane exposure induces impulsive behavioral deficit through disrupting excitatory neurons in the medial prefrontal cortex in mice

摘要

a Schematic diagram showing the cliff avoidance reaction (CAR) test paradigm. The mice were gently put on a platform during the CAR test. b The representative movement traces showing the locations of sevoflurane and control mice in the CAR test. c, d The number of cliff jumping events is higher and the latency of the first jump (the time from an initial placement on the platform until first falling) is significantly shorter in sevoflurane mice. (n = 24 for each group; Mann–Whitney U test). e–g The time spent in the open arms and the number of open arms entries of sevoflurane and control mice make no difference in an elevated plus-maze (EPM) test. Sevoflurane group shows less freezing time in the EPM test. (n = 16 per group; Unpaired Student’s t test for time spent in open arm; Mann–Whitney U test for open arm entries and freezing time.). Data = mean ± SEM; n.s. no significance, *p < 0.05, ***p < 0.001, ****p < 0.0001.