BET family protein degraders poised to join the senolytic arsenal

机译：Bet Family Prote Prodaders准备加入Senolytic Arsenal

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

A proposed mechanism for the senolytic activity of BETd ARV825. ARV825 was found to hijack E3 ligase, leading to degradation of BRD4, inhibition of NHEJ and activation of autophagy, and thus induction of senolysis in senescent cells

机译：一种拟议的煽动性活性β芳烃活性的机制。发现ARV825劫持E3连接酶，导致BRD4的降解，抑制NHEJ和自噬激活，从而诱导衰老细胞

著录项

期刊名称 Signal Transduction and Targeted Therapy
作者
Zufeng Guo; Hanjing Peng; Yongmei Xie;
展开▼
作者单位

展开▼
年(卷),期 2020(-1),-1
年度 2020
页码 -1
总页数 2
原文格式 PDF
正文语种
中图分类生理学;
关键词

机译：化学生物学;药物发现;分子医学;

相似文献

外文文献
中文文献
专利

1. Relation between Family Functioning and Quality of Life among Family Caregivers of Patients with Terminal Cancer Hospitalized in General Wards [J] . Miki Morishita-Kawahara, Takuya Kawahara, Kiyoko Kamibeppu 护理学期刊（英文） . 2020,第012期
2. BET family protein degraders poised to join the senolytic arsenal [J] . Zufeng Guo, Hanjing Peng, Yongmei Xie Signal transduction and targeted therapy. . 2020,第1期

机译：Bet Family Prote Prodaders准备加入Senolytic Arsenal
3. A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells [J] . Masahiro Wakita, Akiko Takahashi, Osamu Sano, Nature Communications . 2020,第1期

机译：赌注家庭蛋白质降解者通过靶向NHEJ和衰老细胞的自噬引起
4. Crystal structure of TTHA0252 from Thermus thermophilus HB8, a RNA degradation protein of the metallo-beta-lactamase superfamily. [J] . Ishikawa H, Nakagawa N, Kuramitsu S, The Journal of Biochemistry . 2006,第4期

机译：TTHA0252的晶体结构来自Thermus热嗜热菌Hb8，Metallo-β-内酰胺酶超家族的RNA降解蛋白。
5. Functional Neighbors: Inferring Relationships between Non-Homologous Protein Families Using Family-Specific Packing Motifs [C] . Bandyopadhyay Deepak, Huan Jun (Luke), Liu Jinze, IEEE International Conference on Bioinformatics and Biomedicine . 2008

机译：功能邻居：使用家用包装基序推断非同源蛋白质家族之间的关系
6. Heat shock protein 70 inhibits heat -induced apoptosis by preventing proteasomal degradation of the anti-apoptotic Bcl-2 family protein Mcl-1 [D] . Stankiewicz, Adam Robert 2008

机译：热休克蛋白70通过防止抗凋亡的Bcl-2家族蛋白Mcl-1的蛋白酶体降解来抑制热诱导的细胞凋亡。
7. Retinoblastoma family proteins: New players in DNA repair by non-homologous end-joining [O] . Paul H. Huang, Rebecca Cook, Georgia Zoumpoulidou, 2016

机译：视网膜母细胞瘤家族蛋白：通过非同源末端连接修复DNA的新参与者
8. Bromodomain and BET family proteins as epigenetic targets in cancer therapy: their degradation, present drugs, and possible PROTACs [O] . Mohd. Muddassir, Kunjal Soni, Chetan B. Sangani, 2021

机译：Bromodomain和Bet Family蛋白作为癌症治疗中的表观遗传靶标：它们的降解，目前药物和可能的protacs

BET family protein degraders poised to join the senolytic arsenal

摘要

著录项

相似文献

相关主题

期刊订阅