P11.15 Exosomal MicroRNA expression profiling altered by high TRAP1 expression in glioblastoma

摘要

Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial molecular chaperone, which regulates the steady state transition between cellular aerobic glycolysis and oxidative phosphorylation. In contrast to normal brain, Glioblastoma multiforme (GBM) shows increased TRAP1 expression. However, the mechanisms responsible for metabolic switch mediated by TRAP1 have not been fully elucidated. Exosomes have been recently implicated in an emerging hallmark of cancer, the cancer cell metabolism. In this study, we studied whether the high expression of TRAP1 can affect the expression profile of miRNAs in the exosomes released by GBM, thus affecting the cell metabolism in the tumor microenvironment.