miRNA expression profile changes in the peripheral blood of monozygotic discordant twins for epithelial ovarian carcinoma: potential new biomarkers for early diagnosis and prognosis of ovarian carcinoma

摘要

The pedigree of the family included in the study and their hierarchical cluster analysis. Legend: The pedigree of the family and using the correlations between samples, plotted a dendrogram for sample grouped by Hierarchical clustering. (Euclidean distance, Complete Linkage) BR 2028: Healthy Brother, BRCA1 negative (non-BRCA1 mutation carrier); BR 1861: Healthy Niece, BRCA1 positive (BRCA1 mutation carrier); BR 1860: Healthy Daughter, BRCA1 negative; BR 1447: Healthy Monozygotic twin, BRCA1 positive (BRCA1 mutation carrier); BR 1639: Monozygotic twin diagnosed with ovarian cancer, BRCA1 positive (BRCA1 mutation carrier); BR 2030: Healthy Sister, BRCA1 positive (BRCA1 mutation carrier); BR 1546: Healthy Sister, BRCA1 positive (BRCA1 mutation carrier); BR 1547: Healthy Sister, BRCA1 positive (BRCA1 mutation carrier)