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The origins and genomic diversity of American Civil War Era smallpox vaccine strains

机译：美国内战时代Smallpox疫苗菌株的起源和基因组多样性

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Mütter Museum vaccination kits. a Left panel, Mütter catalogue # 17090.29 representative vaccination kit containing two vaccination lancets, a small metal box to hold scabrous material and glass slides to hold lymph. Upper right panel, scabrous material from Mütter catalogue # MISC-1090, subsamples of this material were used to produce library VK01. Lower right panel, metal box from Mutter catalogue # 17831.42.16, it is internally divided into four quadrants. The lower two quadrants are filled with a thick hardened residue, and a portion of the same residue remains in the upper left quadrant. This hardened substance, which we believe may be dried lymph, was used to produce library VK08. Photos courtesy of the Mütter Museum of The College of Physicians of Philadelphia. b Relative metagenomic composition of the VK01, VK02, VK05, VK08 and VK12 libraries from shotgun sequencing data and c post orthopoxvirus targeted enrichment. Blue portions represent reads classified as eukaryotic in origin, with the proportion specifically identified as human highlighted. Red portions represent reads classified as viral in origin with a distinction between those assigned specifically to VACV and other OPXV. Orange portions represent reads not classified as either eukaryotic or viral. Post blast analysis, assignments were visualised in Krona [24] and simplified as pie charts produced using ggplot2 [25]

机译：Mütter博物馆疫苗接种套件。左侧面板，Mütter目录＃17090.29代表性疫苗接种套件包含两个疫苗接种刺血针，一个小金属盒，用于保持粘性材料和玻璃载玻片保持淋巴。右上面板，来自Mütter目录＃MISC-1090的舒适材料，使用该材料的载物用于生产库VK01。右下方，Mutter目录的金属盒＃17831.42.16，内部分为四象限。较低的两个象限填充有厚的硬化残渣，并且相同残留物的一部分残留在左上象限。这种硬化物质，我们认为可能是干淋巴，用于生产库VK08。照片由费城医师学院Mütter博物馆提供。 B来自霰弹枪测序数据的VK01，VK02，VK05，VK08和VK12文库的相对偏见组成和C Post Orthopoxvirus靶向富集。蓝色部分表示归类为真核生物的读数，比例明确被识别为人类突出显示。红色部分代表读写作为病毒的读数原点，区别于专门用于验证和其他OPXV的那些。橙色部分表示未归类为真核或病毒的读数。爆炸后分析，在Krona [24]中可视化作业，并简化为使用GGPLOT2产生的饼图[25]

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期刊名称 Genome Biology
作者
Ana T. Duggan; Jennifer Klunk; Ashleigh F. Porter; Anna N. Dhody; Robert Hicks; Geoffrey L. Smith; Margaret Humphreys; Andrea M. McCollum; Whitni B. Davidson; Kimberly Wilkins; Yu Li; Amanda Burke; Hanna Polasky; Lowell Flanders; Debi Poinar; Amogelang R. Raphenya; Tammy T. Y. Lau; Brian Alcock; Andrew G. McArthur; G. Brian Golding; Edward C. Holmes; Hendrik N. Poinar;
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年(卷),期 2020(-1),-1
年度 2020
页码 -1
总页数 11
原文格式 PDF
正文语种
中图分类生物学;
关键词

机译：疫苗接种;天花;痘苗病毒;古代DNA;

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1. The origins and genomic diversity of American Civil War Era smallpox vaccine strains [J] . Ana T. Duggan, Jennifer Klunk, Ashleigh F. Porter, Genome Biology . 2020,第1期

机译：美国内战时代Smallpox疫苗菌株的起源和基因组多样性
2. THE ORIGINS OF THE AMERICAN CIVIL WAR WHAT CAN WE LEARN FROM THE WAY A SOCIETY REMEMBERS A WAR? [J] . BRIAN HOLDEN REID The RUSI journal . 2009,第6期

机译：美国民战的起源我们可以从社会记住战争的方式中学到什么？
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机译：美国内战时代的纪录片：立法成就。大学田纳西州。（内战之声）。 2012.311羽ed。由Thomas C. Mackey.bibliog。指数。国际标准书号（ISBN）9781572338692. $ 49.95
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机译：俄罗斯猪瘟（猪霍乱）病毒的俄语疫苗菌株的传染性基因组副本
5. Cold War and revolution: Soviet-American rivalry and the origins of the Chinese Civil War, 1944-1946. [D] . Westad, Odd Arne. 1990

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6. Genomic Analysis Phenotype and Virulence of the Historical Brazilian Smallpox Vaccine Strain IOC: Implications for the Origins and Evolutionary Relationships of Vaccinia Virus [O] . Maria Luiza G. Medaglia, Nissin Moussatché, Andreas Nitsche, 2015

机译：历史巴西天花疫苗株IOC的基因组分析表型和毒力：对痘苗病毒的起源和进化关系的启示
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8. Operational Maneuver from the American Civil War to the OMG (Operational Maneuver Group). What are Its Origins and Will It Work Today [R] . Shodgrass, J. G. 1988

机译：从美国内战到OmG（作战机动组）的作战机动。它的起源是什么，它今天会起作用

The origins and genomic diversity of American Civil War Era smallpox vaccine strains

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