Letter to the Editor Regarding the Effectiveness of 190 µg Fluocinolone Acetonide and 700 µg Dexamethasone Intravitreal Implants in Diabetic Macular Edema Using the Area-Under-the-Curve Method: The Constant Analysis Article Letter

摘要

In a recent edition of Clinical Ophthalmology, Zarranz-Ventura and Mali presented1 an area-under-the-curve (AUC) analysis that directly compared the best corrected visual acuity (BCVA) improvements in the pivotal diabetic macular edema (DME) trials (FAME and MEAD) for the fluocinolone acetonide implant (Iluvien) and the dexamethasone implant (Ozurdex). They concluded that patients in FAME had superior BCVA improvement over the course of 36 months. We contend that this analysis and the resultant conclusions are flawed because of methodologic deficiencies in the MEAD trial.