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Pathogenic Heteroplasmic Somatic Mitochondrial DNA Mutation Confers Platinum-Resistance and Recurrence of High-Grade Serous Ovarian Cancer

机译：致病性异质体细胞线粒体DNA突变赋予铂抗性和高等血液癌癌的复发性

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摘要

Platinum resistance is a primary barrier to improving the survival rate of ovarian cancer. The relationship between mtDNA somatic mutations and response to platinum-based chemotherapy in ovarian cancer has not been well clarified.

机译：铂抗性是提高卵巢癌的存活率的主要障碍。 MTDNA体细胞突变与对卵巢癌中铂类化疗的反应的关系并未得到很好的澄清。

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期刊名称 Cancer Management and Research
作者
Jing Ni; Yan Wang; Xianzhong Cheng; Fang Teng; Congyang Wang; Suping Han; Xiaoxiang Chen; Wenwen Guo;
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作者单位

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年(卷),期 2020(-1),-1
年度 2020
页码 -1
总页数 9
原文格式 PDF
正文语种
中图分类肿瘤学;
关键词

机译：高级浆液卵巢癌;化疗;异质;线粒体DNA突变;

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专利

1. Pathogenic Heteroplasmic Somatic Mitochondrial DNA Mutation Confers Platinum-Resistance and Recurrence of High-Grade Serous Ovarian Cancer [J] . Jing Ni, Yan Wang, Xianzhong Cheng, Cancer Management and Research . 2020,第3期

机译：致病性异质体细胞线粒体DNA突变赋予铂抗性和高等血液癌癌的复发性
2. Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors [J] . Luísa Pereira, Pedro Soares, Valdemar Máximo, BMC Cancer . 2012,第1期

机译：癌症中的体细胞线粒体DNA突变无法进行纯化选择，而高致病性突变会导致胞浆表型：报道的肿瘤体mtDNA突变的致病性分析
3. Detection of Somatic TP53 Mutations in Tampons of Patients With High-Grade Serous Ovarian Cancer. [J] . Britt K Erickson, Isaac Kinde, Zachary C Dobbin, Obstetrics and Gynecology: Journal of the American College of Obstetricians and Gynecologists . 2014,第5期

机译：高级别浆液性卵巢癌患者棉塞中体细胞TP53突变的检测
4. Fewer Somatic Mutations of Mitochondrial Dna in Noncancerous Liver Tissue of Patients With Hepatocellular Carcinoma Respond To interferon therapy [C] . Shuhei Nishiguchi, Manabk Nishikawa, Masayasu inoue, Yamaguchi Symposium on Liver Disease . 2003

机译：肝细胞癌患者的非癌症肝组织中的线粒体DNA的细胞突变较少，对干扰素治疗反应
5. Characterization of Precancerous Mutations in Ulcerative Colitis-Associated Colorectal Cancer and High-Grade Serous Ovarian Cancer via Duplex Sequencing [D] . Baker, Kathryn Terese 2018

机译：溃疡性结肠炎相关大肠癌和高级别浆液性卵巢癌癌前突变的双重测序表征。
6. Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors [O] . Luísa Pereira, Pedro Soares, Valdemar Máximo, 2012

机译：癌症中的体细胞线粒体DNA突变无法进行纯化选择而高致病性突变会导致胞浆表型：报道的肿瘤体mtDNA突变的致病性分析
7. >Pathogenic Heteroplasmic Somatic Mitochondrial DNA Mutation Confers Platinum-Resistance and Recurrence of High-Grade Serous Ovarian Cancer [O] . Jing Ni, Yan Wang, Xianzhong Cheng, 2020

机译：致病性异质体细胞线粒体DNA突变赋予铂抗性和高等血液癌癌的复发

Pathogenic Heteroplasmic Somatic Mitochondrial DNA Mutation Confers Platinum-Resistance and Recurrence of High-Grade Serous Ovarian Cancer

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