Sex differences in mouse models of fear inhibition: Fear extinction safety learning and fear–safety discrimination

摘要

Women are overrepresented in post‐traumatic stress disorder (PTSD), a mental disorder characterised by ineffective inhibition of fear. The use of male animals dominates preclinical studies, which may contribute to a lack of understanding as to why this disparity exists. Thus, the current study explores sex differences in three mouse models of fear inhibition.