PDXGEM: patient-derived tumor xenograft-based gene expression model for predicting clinical response to anticancer therapy in cancer patients

摘要

Schema of the patient-derived xenograft based gene expression model (PDXGEM). a In the drug sensitivity gene discovery step, correlation analysis and differential expression analysis of gene expression data and drug-activity data in patient-derived xenograft (PDX) tumors are conducted. b Concordant co-expression analysis identifies a drug sensitivity gene (g1) that is concordantly co-expressed with 3 other genes (g2, g3, and g4) between PDX tumors and pretreatment cancer patients’ tumors. c A multi-gene expression model of drug response is trained on PDX data using the random-forest algorithm. d The performance of the multi-gene expression model is validated by contrasting prediction scores between the responsive (R) and the non-responsive (NR) patients to a drug in cancer patient cohort