ImmunoGlobe: enabling systems immunology with a manually curated intercellular immune interaction network

摘要

ImmunoGlobe is a directional immune interaction network that was constructed by manually codifying immune interactions described in the Janeway’s Immunobiology 9e textbook. a Schematic showing information recorded for each interaction. Each interaction is composed of at least a source node, target node, edge effect and source text reference. Bold text indicates required information for each edge; other points were recorded when available. b An example sentence showing the codification process. Seven interactions described in this sentence are annotated, with arrows originating at each source node and ending at each target node. Numbers on the arrows correspond to the “Interaction” column in 1c. Highlight colors of words in 1b correspond to the highlight colors in 1c. c The information extracted from sentence 1b is recorded into a network table. Each interaction between two nodes is recorded in its own row. Some rows have more detail than others, but all contain the required information (detailed in 1a). d The network table is used to generate a graphical representation of the described immune interactions. The entirety of the Janeway textbook was codified as illustrated here