C1orf109L binding DHX9 promotes DNA damage depended on the R‐loop accumulation and enhances camptothecin chemosensitivity

摘要

R‐loop is a three‐stranded nucleic acid structure of RNA/DNA hybrid, which occurs naturally during transcription, and more R‐loop accumulation can trigger serious DNA damage. There has been increasing attention to the issue of R‐loop accumulation acted as a target for cancer therapy. However, the regulation of R‐loop‐associated proteins is poorly explored.