Brutons Tyrosine Kinase: A Promising Target for the Treatment of COVID-19

摘要

Coronavirus Disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 in China and quickly spread throughout the world. By June 24, 2020, the World Health Organization (WHO) reported the total number of 8,993,659 laboratory-confirmed cases leading to 469,587 deaths worldwide (1). COVID-19 has a range of clinical manifestations from asymptomatic cases to severe and life-threatening illnesses (2). The most severe form of the disease is the rapidly progressing failure of the respiratory system, presenting by severe dyspnea and profound hypoxemia, and may lead to acute respiratory distress syndrome (ARDS)(3) .