Human umbilical cord-derived mesenchymal stem/stromal cells: a promising candidate for the development of advanced therapy medicinal products

摘要

Manufacturing and mechanisms of action of an UC-MSC-based-ATMP. a The manufacturing of UC-MSC-based-ATMPs including the UC donation and procurement according to the European directive 2004/23/EC and then the drug manufacturing and quality controls according to GMP specific to ATMP. b In vitro mechanisms of action of UC-MSCs in pro-inflammatory conditions, on adaptative (left) and innate immunity (right)