Cancer Environment Immunotherapy: targeting TGF-β finds its way towards tissue healing and vasculature remodeling

摘要

Blockage of TGF-β signaling in CD4+ T cells by 4T-Trap reprograms tumor vasculature and halts cancer progression. a In a well-developed solid tumor (e.g., breast cancer), the irregular and abundant vasculature in the local “hotbed” could fully support tumor growth and compromise the outcome of cancer therapies. b Blockade of TGF-β signaling in CD4+ T cells with 4T-Trap results in enhanced Th2 cell differentiation that promotes vasculature remodeling and tumor tissue healing with cancer cell hypoxia and death in avascular regions. 4T-Trap probably represents a novel modality of “cancer environment immunotherapy”