TGFβ/cyclin D1/Smad-mediated inhibition of BMP4 promotes breast cancer stem cell self-renewal activity

摘要

a TGFβ effects on tumorsphere formation. Data are expressed as mean ± standard error. *P ≤ 0.05, n.s. not significant. b Pearson correlations and (c) normalized counts across all bioreplicates. d Volcano plot of differential expressed genes (red and blue indicate up- and downregulated genes, respectively (FDR < 0.05). e Gene ontology enrichment analysis of 290 candidate genes (FDR < 0.05) using EnrichR. f Heatmaps of the TGFβ-regulated biological processes.