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NUSAP1 Accelerates Osteosarcoma Cell Proliferation and Cell Cycle Progression via Upregulating CDC20 and Cyclin A2

机译：Nusap1通过上调CDC20和Cyclin A2加速骨肉瘤细胞增殖和细胞周期进展

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摘要

Nucleolar and spindle-associated protein 1 (NUSAP1) is a significant mitotic regulator and has been found to be implicated in carcinogenesis of several cancers. The aim of this study was to explore the functional role and underlying mechanisms of NUSAP1 in osteosarcoma.

机译：核仁和主轴相关蛋白1（NUSAP1）是一种重要的有丝分裂调节剂，已被发现涉及几种癌症的致癌作用。本研究的目的是探讨NUSAP1在骨肉瘤中的功能作用和潜在机制。

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期刊名称 OncoTargets and therapy
作者
Haoran Wang; Zixiang Liu; Peng Wu; Hanqing Wang; Weiwei Ren;
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作者单位

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年(卷),期 2021(-1),-1
年度 2021
页码 -1
总页数 12
原文格式 PDF
正文语种
中图分类应用微生物学 ; 肿瘤学 ;
关键词
NUSAP1; osteosarcoma; CDC20; cyclin A2; cell cycle;

机译：NUSAP1;骨肉瘤;CDC20;CYCLIN A2;细胞周期;

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专利

1. EVI1 targets DELTANp63 and upregulates the cyclin dependent kinase inhibitor p21 independent of p53 to delay cell cycle progression and cell proliferation in colon cancer cells [J] . Kasturi Bala Nayak, Nivedita Kuila, Alok Das Mohapatra, The international journal of biochemistry and cell biology . 2013 ,第8期

机译：EVI1靶向DELTANp63，并独立于p53上调细胞周期蛋白依赖性激酶抑制剂p21，从而延迟结肠癌细胞的细胞周期进程和细胞增殖
2. Long non-coding RNAs HERH-1 and HERH-4 facilitate cyclin A2 expression and accelerate cell cycle progression in advanced hepatocellular carcinoma [J] . Liu Tao, Shi Qiao, Yang Lei, BMC Cancer . 2021 ,第1期

机译：长期非编码RNA-1和Herh-4促进细胞周期蛋白A2表达并加速细胞周期进展在晚期肝细胞癌中
3. Knockdown of receptor tyrosine kinase-like orphan receptor 2 inhibits cell proliferation and colony formation in osteosarcoma cells by inducing arrest in cell cycle progression [J] . Huang Jianjun, Shi Ying, Li Hui, Oncology letters . 2015 ,第6期

机译：敲除受体酪氨酸激酶样孤儿受体2，通过诱导细胞周期进程停滞，抑制骨肉瘤细胞增殖和集落形成
4. Increased proliferation of primary chondrocyte cells by nanostructure and cycling mechanical stimulation on PDMS cell chip [C] . Chen Tsung-Ju, Lin Tung-Yi, Wang Yu-Ling, IEEE International Conference on Micro Electro Mechanical Systems . 2013

机译：通过PDMS细胞芯片上的纳米结构和循环机械刺激提高原代软骨细胞的增殖
5. Anti -inflammatory mechanisms of minocycline: Suppression of T cell proliferation, activation and cell cycle progression [D] . Brice, Angela K. 2009

机译：米诺环素的抗炎机制：抑制T细胞增殖，活化和细胞周期进程
6. Knockdown of receptor tyrosine kinase-like orphan receptor 2 inhibits cell proliferation and colony formation in osteosarcoma cells by inducing arrest in cell cycle progression [O] . JIANJUN HUANG, YING SHI, HUI LI, -1

机译：敲除受体酪氨酸激酶样孤儿受体2通过诱导细胞周期进程停滞抑制骨肉瘤细胞增殖和集落形成
7. Karyopherin subunit-α 2 expression accelerates cell cycle progression by upregulating CCNB2 and CDK1 in hepatocellular carcinoma [O] . Chun‑Lin Gao, Gao‑Wei Wang, Guan‑Qin Yang, 2017

机译：Karyopherin亚基-α2表达通过在肝细胞癌中的CCNB2和CDK1上调CCNB2和CDK1来加速细胞周期进展

NUSAP1 Accelerates Osteosarcoma Cell Proliferation and Cell Cycle Progression via Upregulating CDC20 and Cyclin A2

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