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Drying Behavior and Kinetics of Drying Process of Plant-Based Enteric Hard Capsules

机译:植物肠溶胶囊干燥过程的干燥行为和动力学

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摘要

The drying process is a significant step in the manufacturing process of enteric hard capsules, which affects the physical and chemical properties of the capsules. Thus, the drying characteristics of plant-based enteric hard capsules were investigated at a constant air velocity of 2 m/s in a bench scale hot-air dryer under a temperature range of 25 to 45 °C and relative humidity of 40 to 80%. Results indicate that the drying process of the capsules mainly occur in a falling-rate period, implying that moisture transfer in the capsules is governed by internal moisture diffusion rate. High temperature and low relative humidity reduce drying time but increase the drying rate of the capsules. Investigation results of the mechanical properties and storage stability of the capsules, however, reveal that a fast drying rate leads to plant-based enteric hard capsules of low quality. Scanning electron microscopy further demonstrates that more layered cracks appear in capsules produced under a faster drying rate. The Page model yielded the best fit for describing thin-layer drying of the capsules based on the coefficient of determination and reduced chi-square. Moreover, it was established that the effective moisture diffusivity of the capsules increases with an increase in drying temperature or reduction in relative humidity.
机译:干燥过程是肠溶硬胶囊的制造过程中的重要步骤,这影响了胶囊的物理和化学性质。因此,在25至45℃的温度范围内的恒定空气速度为2m / s的恒定空气速度,在25至45℃,相对湿度为40%至80%的情况下,在2m / s的恒定空气速度下进行植物肠溶硬胶囊的干燥特性。 。结果表明,胶囊的干燥过程主要发生在下降率时期,这意味着胶囊中的水分转移受内部水分扩散速率的控制。高温和低相对湿度降低干燥时间,但增加了胶囊的干燥速率。然而,胶囊的机械性能和储存稳定性的调查结果表明,快速干燥速率导致植物的肠溶硬胶囊低质量。扫描电子显微镜进一步证明了更多层状裂缝出现在更快的干燥速率下产生的胶囊中。页面模型产生最合适的适合,用于基于测定系数和减少Chi-Square的薄层干燥。此外,建立了胶囊的有效水分扩散率随着干燥温度或相对湿度的增加而增加。

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