Real-World Inpatient Use of Medications Repurposed for Coronavirus Disease 2019 in United States Hospitals March–May 2020

摘要

We report off-label use patterns for medications repurposed for coronavirus disease 2019 (COVID-19) at 318 US hospitals. Inpatient hydroxychloroquine use declined by 80%, whereas corticosteroids and tocilizumab were initiated 2 days earlier in May versus March 2020. Two thirds of ventilated COVID-19 patients were already receiving corticosteroids during March–May 2020, resembling pre-COVID use in mechanically ventilated influenza patients.