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α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 Ameliorates Cognitive Impairment Induced by Chronic Intermittent Hypoxia

机译：α7烟碱乙酰胆碱受体激动剂PNU-282987改善慢性间歇性缺氧诱导的认知障碍

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摘要

Cognitive impairment is an important complication of obstructive sleep apnea (OSA). Chronic intermittent hypoxia (CIH), the main pathophysiological characteristics of OSA, is closely related to cognitive dysfunction and may be mediated by alpha-7 nicotinic acetylcholine receptors (α7nAChR). This study investigated the effects and clarified the mechanisms of α7nAChR on the cognitive function of mice with CIH.

机译：认知障碍是阻塞性睡眠呼吸暂停（OSA）的重要并发症。慢性间歇性缺氧（CIH），OSA的主要病理生理学特征与认知功能障碍密切相关，并且可以由α-7烟碱乙酰胆碱受体（α7NACHR）介导。本研究研究了α7NAChr的作用并阐明了CIH的小鼠认知功能的影响。

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期刊名称 Nature and Science of Sleep
作者
Hui Shen; Yanling Meng; Dan Liu; Zheng Qin; Hong Huang; Lei Pan; Wei Wang; Jian Kang;
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作者单位

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年(卷),期 2021(-1),-1
年度 2021
页码 -1
总页数 12
原文格式 PDF
正文语种
中图分类
关键词
hypoxemia; cognitive dysfunction; nicotinic acetylcholinergic receptor alpha7 subunit; CREB; BDNF; obstructive sleep apnea;

机译：低氧血症;认知功能障碍;烟碱乙酰胆碱能受体α7亚基;CREB;BDNF;阻塞性睡眠呼吸暂停;

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1. Alpha7 nicotinic acetylcholine receptor-specific agonist DMXBA (GTS-21) attenuates Aβ accumulation through suppression of neuronal γ-secretase activity and promotion of microglial amyloid-β phagocytosis and ameliorates cognitive impairment in a mouse model of Alzheimer's disease [J] . Kazuyuki Takata, Takahide Amamiya, Hiroaki Mizoguchi, Neurobiology of Aging: Experimental and Clinical Research . 2018,第期

机译：α7烟碱乙酰胆碱受体特异性激动剂DMXBA（GTS-21）通过抑制神经元γ-分泌酶活性和促进小鼠阿尔茨海默病的小鼠模型中的微胶质淀粉样蛋白-β吞噬作用和改良认知障碍的Aβ积累
2. alpha 7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling [J] . Hasan Mohammad Kamrul, Friedman Theodore C., Sims Carl, Endocrinology . 2018,第2期

机译：α7-烟碱乙酰胆碱受体激动剂通过抑制氧化应激和刺激AMPK信号传导，改善尼古丁加上高脂饮食诱导的肝脏脂肪变性
3. alpha 7-Nicotinic Acetylcholine Receptor Agonist Ameliorates Nicotine Plus High-Fat Diet-Induced Hepatic Steatosis in Male Mice by Inhibiting Oxidative Stress and Stimulating AMPK Signaling (vol 159, pg 931, 2018) [J] . Hasan M. K., Friedman T. C., Sims C., Endocrinology . 2018,第3期

机译：α7-烟碱乙酰胆碱受体激动剂通过抑制氧化应激和刺激AMPK信号传导（Vol 159，PG 931,2018），在雄性小鼠中改善尼古丁加上高脂饮食诱导的肝脏脂肪变性（Vol 159，PG 931,2018）
4. Hypoxia-induced overexpression of #x03B1;lpha5 nicotinic acetylcholine receptor of human lung cancer cell lines [C] . Ying Jia, Yanfei Jia, Shanshan Zu, 2014 IEEE Workshop on Electronics, Computer and Applications . 2014

机译：缺氧诱导人肺癌细胞株αl5烟碱型乙酰胆碱受体过表达
5. The Mechanisms Underlying Cognitive Impairment Induced by Chronic Intermittent Hypoxia in Rodents [D] . Xu, Linhao. 2014

机译：啮齿类动物慢性间歇性低氧引起认知障碍的机制
6. A Selective α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 Attenuates ILC2s Activation and Alternaria-Induced Airway Inflammation [O] . Fang Yuan, Lili Jiang, Qianyang Li, 2020

机译：一种选择性α7烟碱乙酰胆碱受体激动剂PNU-282987衰减ILC2S活化和alternaria诱导的气道炎症
7. A Selective α7 Nicotinic Acetylcholine Receptor Agonist, PNU-282987, Attenuates ILC2s Activation and Alternaria-Induced Airway Inflammation [O] . Fang Yuan, Lili Jiang, Qianyang Li, 2021

机译：一种选择性α7烟碱乙酰胆碱受体激动剂，PNU-282987，衰减ILC2S活化和alternaria诱导的气道炎症

α7 Nicotinic Acetylcholine Receptor Agonist PNU-282987 Ameliorates Cognitive Impairment Induced by Chronic Intermittent Hypoxia

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