Platelet abnormalities and platelet-to-lymphocyte ratios in canineimmunosuppressant-responsive and non-responsive enteropathy: A retrospective study in 41dogs

摘要

Few studies have examined platelet alterations in dogs with chronic enteropathy. Our aimwas to investigate platelet count (PLT), mean platelet volume (MPV), andplatelet-to-lymphocyte ratio (PLR) in dogs diagnosed with immunosuppressant-responsiveenteropathy (IRE). In this retrospective study of 41 dogs, data regarding signalment,canine chronic enteropathy clinical activity index (CCECAI), endoscopic andhistopathological scores, PLT, MPV, PLR, total serum protein concentrations, albumin, andiron were collected. Clinical response and relapse were assessed with the evaluation ofCCECAI over time. One month after starting therapy, dogs with >25% CCECAI reductionwere considered responders. During a three-month CCECAI evaluation as part of atwelve-month follow-up, a CCECAI >3 together with a ≥2 unit increase in responder dogswas considered a relapse. PLT and PLR displayed significant negative correlation with MPV.MPV was positively correlated with total protein and albumin levels and negativelycorrelated with CCECAI. Three dogs were classified as non-responders, and 14 relapsedwithin 12 months. No differences were observed in PLT, MPV, or PLR betweenrespondingon-responding and relapsingon-relapsing groups. PLT, MPV, and PLR correlatedwith total protein, albumin, and CCECAI, confirming PLT as a potential marker, andsuggesting MPV as a new marker of clinical efficacy against canine IRE.