Can sacubitril/valsartan become the promising drug to delay the progression of chronic kidney disease?

摘要

Chronic kidney disease (CKD) often coexists with or is a complication of cardiovascular disease. Previous studies have shown that CKD increases the risk of cardiovascular death and all-cause death and was considered to be a risk equivalent of coronary heart disease.[1, 2] Adjusted for confounders, decreased glomerular filtration rate (GFR) and increased albuminuria are both independent risk factors for cardiovascular events.[3, 4] The risk for cardiovascular death linearly increases with the decline of GFR in a certain range (< 70 mL/min per 1.73 m2) and the increase of albuminuria without a threshold effect.[3]