USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway

机译：USP15通过抑制PI3K / AKT信号传导途径来促进退化核骨髓细胞的凋亡

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摘要

Degenerative disc disease is characterized by an enhanced breakdown of its existing nucleus pulposus (NP) matrix due to the dysregulation of matrix enzymes and factors. Ubiquitin‐specific protease 15 (USP15) is reported to be abnormal in certain human diseases. However, its role in NP degeneration remains unclear. Therefore, we aimed to explore the function of USP15 in degenerative NP cell specimens.

机译：退行性椎间盘疾病的特征在于，由于基质酶和因子的失调，其现有的核髓（NP）基质的增强分解。据报道，泛素特异性蛋白酶15（USP15）在某些人类疾病中被异常。然而，其在NP退化中的作用仍然不清楚。因此，我们旨在探讨USP15在退化NP细胞标本中的功能。

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期刊名称 Journal of Cellular and Molecular Medicine
作者
Bin Yu; Bin Shen; Zhaoyu Ba; Zhonghan Liu; Jing Yuan; Weidong Zhao; Desheng Wu;
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作者单位

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年(卷),期 2020(24),23
年度 2020
页码 13813–13823
总页数 11
原文格式 PDF
正文语种
中图分类细胞生物学;医学史;
关键词
AKT; degenerative nucleus pulposus; FK506‐binding protein 5; miR‐338‐3p; ubiquitin‐specific protease 15;

机译：akt;退化核脉搏;FK506结合蛋白5;mir-338-3p;泛素特异性蛋白酶15;

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专利

1. Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways [J] . Mingyan Yao, Jing Zhang, Zhihong Li, Frontiers in Medicine . 2021,第a期

机译：Liraglutide通过激活PI3K / AKT / MTOR / CASPASE-3和PI3K / AKT /GSK3β/ Caspase-3信号通路来保护核牙髓细胞对高葡萄糖诱导的细胞凋亡
2. Low Intensity Pulsed Ultrasound Promotes the Extracellular Matrix Synthesis of Degenerative Human Nucleus Pulposus Cells Through FAK/PI3K/Akt Pathway [J] . Zhang XiaoJun, Hu ZhenMing, Hao Jie, Spine . 2016,第5期

机译：低强度脉冲超声通过FAK / PI3K / Akt途径促进变性人核髓细胞的细胞外基质合成
3. Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal. [J] . Risbud MV, Fertala J, Vresilovic EJ, Spine . 2005,第8期

机译：缺氧条件下髓核细胞上调PI3K / Akt和MEK / ERK信号通路，抵抗血清停药诱导的凋亡。
4. Determining the functional role of keratin filaments in apoptosis via the PI3K/Akt signaling pathway using LTQ Orbitrap MS/MS analysis [C] . Nancy Fernandes, Nicole Morin Jaskiewicz, David H. Townson, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：使用LTQ orbitrap MS / MS分析确定通过PI3K / AKT信号通路凋亡中角蛋白长丝在细胞凋亡中的功能作用
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways [O] . Mingyan Yao, Jing Zhang, Zhihong Li, 2021

机译：Liraglutide通过激活PI3K / AKT / MTOR / Caspase-3和PI3K / Akt /GSK3β/ Caspase-3信号通路来保护核骨盆细胞免受高葡萄糖诱导的细胞凋亡
7. USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway [O] . Bin Yu, Bin Shen, Zhaoyu Ba, 2020

机译：USP15通过抑制PI3K / AKT信号传导途径来促进退化核骨髓细胞的凋亡

USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway

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