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Molecular Regulation of Lipogenesis Adipogenesis and Fat Deposition in Chicken

机译:脂肪发生脂肪生成和脂肪沉积在鸡肉中的分子调节

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摘要

In the poultry industry, excessive fat deposition is considered an undesirable factor, affecting feed efficiency, meat production cost, meat quality, and consumer’s health. Efforts to reduce fat deposition in economically important animals, such as chicken, can be made through different strategies; including genetic selection, feeding strategies, housing, and environmental strategies, as well as hormone supplementation. Recent investigations at the molecular level have revealed the significant role of the transcriptional and post-transcriptional regulatory networks and their interaction on modulating fat metabolism in chickens. At the transcriptional level, different transcription factors are known to regulate the expression of lipogenic and adipogenic genes through various signaling pathways, affecting chicken fat metabolism. Alternatively, at the post-transcriptional level, the regulatory mechanism of microRNAs (miRNAs) on lipid metabolism and deposition has added a promising dimension to understand the structural and functional regulatory mechanism of lipid metabolism in chicken. Therefore, this review focuses on the progress made in unraveling the molecular function of genes, transcription factors, and more notably significant miRNAs responsible for regulating adipogenesis, lipogenesis, and fat deposition in chicken. Moreover, a better understanding of the molecular regulation of lipid metabolism will give researchers novel insights to use functional molecular markers, such as miRNAs, for selection against excessive fat deposition to improve chicken production efficiency and meat quality.
机译:在家禽行业中,过度脂肪沉积被认为是一种不良因素,影响饲料效率,肉类生产成本,肉质和消费者的健康。可以通过不同的策略来减少经济上重要的动物的脂肪沉积的努力;包括遗传选择,喂养策略,住房和环境策略以及激素补充剂。最近在分子水平的调查揭示了转录和转录后调节网络的重要作用及其对鸡中调节脂肪代谢的相互作用。在转录水平下,已知不同的转录因子来调节通过各种信号通路的脂质和脂肪基因的表达,影响鸡脂肪代谢。或者,在转录后水平,MicroRNAS(miRNA)对脂质代谢和沉积的调节机制增加了有希望的尺寸,以了解鸡脂质代谢的结构和功能调节机制。因此,本综述重点介绍在解开基因,转录因子和更明显显着的MIRNA的分子函数方面取得的进展,这些乳腺癌负责调节脂肪发生,脂肪生成和鸡肉中的脂肪沉积。此外,更好地了解脂质代谢的分子调控将使研究人员新颖的见解使用功能分子标记,例如miRNA,以选择过度脂肪沉积,以提高鸡肉生产效率和肉质。

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