Histone H3K9 and H3K14 acetylation at the promoter of the

摘要

Altered expression of the LGALS9 gene has been reported for several cancer types. This study showed that increased histone acetylation at the LGALS9 promoter was associated with higher mRNA levels of LGALS9. In a nontumoral cell line, HaCaT, the LGALS9 gene presented higher levels of histone acetylation than in cervical cancer cells. Our work suggests that epigenetic mechanisms may regulate the expression of the LGALS9 gene during tumor transformation.