Prototype foamy virus downregulates RelB expression to facilitate viral replication

摘要

Foamy viruses (FVs) establish lifelong latent infections without evident pathology in the host. The roles of cellular factors in FV replication are poorly understood. In this study, we demonstrate that RelB interacts with PFV Tas, and RelB decreases Tas‐dependent transactivation of PFV gene expression in turn. PFV infection downregulates the viral inhibitory host factor RelB, which otherwise restricts viral gene expression.