Infections of the lung: a predictive preventive and personalized perspective through the lens of evolution the emergence of SARS-CoV-2 and its pathogenesis

摘要

Exploiting host-pathogen interactions for clinically useful targets: Evolutionary arms race between pathogen and host has led to the evolution of potent immune and cellular mechanisms that are counter-adapted by immune modulation strategies by the pathogens. At the site of gaseous exchange, lungs, and easily accessible niche has been evolutionarily targeted by many pathogens. They evade the immune system and inflict significant diseases in the susceptible host population. Further understanding of these immune evasive tactics and host variability can assist in the design and development of personalized therapies