Lipid Traffic Analysis reveals the impact of high paternal carbohydrate intake on offsprings’ lipid metabolism

摘要

a Schematic representation of the mouse model showing the generation of programmed offspring across two generations. b The network that describes the lipid traffic associated with de novo lipogenesis from the liver to termini (CNS, heart and adipose) via the serum. The termini represent traffic for structural purposes (CNS), fatty acid oxidation (heart) and storage (adipose). This metabolic relationship between tissues was used as the structure of the network for all analyses in the present study. Adipose was not available for neonates and thus networks for F1N and F2N do not include this tissue. Cerebellum and right hemispheres of the brains of the F1A and F2N groups, enabling separate analysis of cortices and the cerebellum in these groups. NP-NC refers to a diet of normal protein-normal carbohydrate where LP-HC refers to a low protein-high carbohydrate diet. The NP-NC and LP-HC are the same as NN and LL groups used in earlier studies2,15.