Association between sarcopenia and cognitive impairment in community-dwelling population

摘要

Cognitive impairment is a neurodegenerative change, involving the progression from mild cognitive impairment to dementia.[1] Sarcopenia is often considered geriatric and is characterized by a progressive and generalized decrease in skeletal muscle mass and strength.[2] Interestingly, several common pathogenic mechanisms are involved in both sarcopenia and cognitive disorders. The risk factors for sarcopenia include mitochondrial dysfunction, oxidative stress, chronic inflammation, and hormonal changes, all of which are potential causes of cognitive impairment.[3] Consequently, cognitive impairment may be closely related to sarcopenia. This study aims to examine the relationship between cognitive impairment and sarcopenia among community-dwelling elderly adults.