Interplay between p53 and non-coding RNAs in the regulation of EMT in breast cancer

摘要

р53 mediates expression of the indicated miRs (denoted with blue color) that in turn target Zeb1/2 EMT-TFs (denoted as burgundy-colored boxes). Long non-coding RNAs (lncRNAs) denoted with pink-color act as competing endogenous RNAs (ceRNAs) to counteract the effect of miRs. Interactions between all of these players form simple links and feedback loops (indicated with arrows and bars). Positive influence is denoted by blue arrows and negative is denoted by red bars.