The intragraft vascularized bone marrow component plays a critical role in tolerance induction after reconstructive transplantation

摘要

VBM transplantation with CoB and RPM resulted in prolonged VCA survival. a Experimental design. b Immunosuppression protocol. c Graft tolerance in the high CBMT and VBM transplantation groups is represented clinically by normal hair growth. In contrast, graft rejection in the no CBMT and low CBMT groups showed erythema and hair loss of the transplanted flap. d Kaplan–Meier survival analysis of flaps in the syngeneic group, n = 4; alloMC group, n = 6; high CBMT group, n = 6; low CBMT group, n = 6; and VBM transplantation group, n = 6. The no CBMT group vs VBM transplantation group and low CBMT group vs VBM transplantation group were significantly different (p < 0.05).