CD147 deficiency in T cells prevents thymic involution by inhibiting the EMT process in TECs in the presence of TGFβ

摘要

a Photograph of thymuses isolated from the CD147T-KO mice and wild-type mice at 6, 12, and 36 weeks. b Weights of the thymuses isolated from CD147T-KO mice and wild-type mice at 6, 12, and 36 weeks. c Total thymocytes in the CD147T-KO mice and wild-type mice at 6, 12, and 36 weeks. d Hematoxylin-eosin stained thymuses isolated from the CD147T-KO mice and wild-type mice at 6, 12, and 36 weeks (100×). e TUNEL staining showing apoptosis in the DP cells at 12 weeks. f Flow cytometry analysis of the naïve T cells in blood collected from the CD147T-KO mice and wild-type mice at 36 weeks. g Oil red O staining showing lipid accumulation in the thymus of the CD147T-KO mice and wild-type mice at 6, 12, and 36 weeks (400×). h UCP-1 expression in the thymus of the CD147T-KO mice and wild-type mice at 6, 12, and 36 weeks (200×). The data are representative of three or four experiments.