Structure of the full-length human Pannexin1 channel and insights into its role in pyroptosis

摘要

a Cryo-EM density map of hPANX1 at a resolution of 3.15 Å with each subunit color-coded from a side view. b Ribbon representation of the heptameric hPANX1-MD structure from the side view and the bottom view with each subunit color-coded. The glycosylation moieties are shown as sticks. c Schematic representation of the secondary structure of hPANX1. Cylinders and arrows indicate helices and β-strands, respectively. d Ribbon representation of the hPANX1-MD protomer structure with different regions colored.