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Impetigo Animal Models: A Review of Their Feasibility and Clinical Utility for Therapeutic Appraisal of Investigational Drug Candidates

机译:Impetigo Animal Models:对调查药物候选人治疗评估的可行性和临床效用综述

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摘要

Impetigo (school sores), a superficial skin infection commonly seen in children, is caused by the gram-positive bacteria Staphylococcus aureus and/or Streptococcus pyogenes. Antibiotic treatments, often topical, are used as the first-line therapy for impetigo. The efficacy of potential new antimicrobial compounds is first tested in in vitro studies and, if effective, followed by in vivo studies using animal models and/or humans. Animal models are critical means for investigating potential therapeutics and characterizing their safety profile prior to human trials. Although several reviews of animal models for skin infections have been published, there is a lack of a comprehensive review of animal models simulating impetigo for the selection of therapeutic drug candidates. This review critically examines the existing animal models for impetigo and their feasibility for testing the in vivo efficacy of topical treatments for impetigo and other superficial bacterial skin infections.
机译:Impetigo(学校疮),常见于儿童常见的浅表皮肤感染,是由革兰氏阳性细菌金黄色葡萄球菌和/或链球菌的粘附剂引起的。抗生素治疗通常是局部的,用作Impetigo的一线治疗。潜在的新抗微生物化合物的疗效首先在体外研究中进行测试,并且如果有效,然后使用动物模型和/或人类的体内研究。动物模型是针对人类试验之前研究潜在治疗方法并表征其安全性曲线的关键手段。虽然已发表了几次对皮肤感染动物模型的动物模型,但缺乏对模拟Impetigo的动物模型进行全面审查,以便选择治疗药物候选者。本综述批判性地检查了普通普通的现有动物模型及其可行性,用于测试Impetigo和其他浅表细菌皮肤感染的局部治疗的体内疗效。

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