Cornelian Cherry Pulp Has Beneficial Impact on Dyslipidemia and Reduced Bone Quality in Zucker Diabetic Fatty Rats

摘要

Fruits of Cornelian cherry (Cornus mas L.) are often used as an antidiabetic supplement mainly due to their hypoglycemic properties. A very important aspect and secondary complication of type 2 diabetes mellitus (T2DM) represents diabetic bone disease. In our study, the impacts of Cornus mas pulp on lipid profile and bone quality parameters were evaluated in Zucker diabetic fatty (ZDF) rats as a well-matched T2DM animal model. We demonstrated, for the first time, that Cornelian cherry pulp could be used as a potential therapeutic agent to alleviate T2DM-reduced bone quality and impaired bone health. Moreover, the hypolipidemic effect of this fruit was also confirmed in our study.