Role of JAK-STAT Pathway in Broiler Chicks Fed with Chestnut Tannins

摘要

Current bans on the use of antibiotics in livestock feed have led to increasing demand for alternatives to antibiotics (ATA). One popular alternative is chestnut tannins (ChT). While there is growing evidence of the immune benefits of using phytobiotics, such as ChT, there is currently minimal information on the effect of tannins on the immune pathway of the host. A previous study discovered a large upregulation of IL-6 in broiler chicks at day 6 when provided with 1% ChT from hatch. In regard to potential immune modulation, ChT appear to influence host immunity via an IL-6 mediated response, which could be beneficial in host defenses against pathogens at the early stages of broiler growth and development. A critical pathway identified in the regulation of the immune system is the JAK-STAT signaling pathway. The role of JAK-STAT pathway is altered by the addition of ChT in the diet. By demonstrating the changes in the kinome of the broiler model, the information in this study will provide further insights into potential ATA to improve poultry health.