Comorbidity between Alzheimer’s disease and major depression: a behavioural and transcriptomic characterization study in mice

摘要

APP/PSEN1-Tg animals show early anxiety-like and despair-like behaviours induced by stress. Panels a, b, d and e represent the EPM results, and panels c and f correspond to the TST results. Grey (non-transgenic) and yellow (APP/PSEN1-Tg) bars represent the percentage of time spent in open arms (a, d) and total number of entries (b, e) at 3 (n = 16 per group) and 6 months (n = 14 per group) (*p < 0.05, Student’s t-test non-transgenic vs APP/PSEN1-Tg). Grey (non-transgenic) and yellow (APP/PSEN1-Tg) bars represent the percentage of time that animals are immobile in TST at 3 (n = 16 per group) (c) and 6 months old (non-transgenic n = 12, APP/PSEN1-Tg n = 14) (f) in pre-stress and post-stress conditions. Data are presented as mean ± SEM. ***p < 0.001 pre-stress vs post-stress condition; +++p < 0.001 comparison of APP/PSEN1-Tg pre-stress vs post-stress; **p < 0.01 comparison of APP/PSEN1-Tg vs non-transgenic post-stress condition (two-way ANOVA)