Podoplanin mediates the renoprotective effect of berberine on diabetic kidney disease in mice

摘要

Blood glucose (a), renal function (b, c), and podocyte ultrastructural changes (d) in streptozotocin (STZ)-induced diabetic mice. After mice were injected with STZ, fasting blood glucose level, renal function (including the serum creatinine and albumin/creatinine ratio level) were determined at different time intervals as indicated. To observe the ultrastructural changes of podocytes in early stages of diabetic kidney disease, electron microscopic examination was performed (magnification ×4400). The arrows designate different structures of the glomerulus: white arrows, normal foot processes; black arrows, normal glomerular basement membrane; red arrows, fused foot processes. Con control group, STZ STZ-induced diabetic group. The data are expressed as the mean ± SEM (n = 3 per time point). *P < 0.05, **P < 0.01 compared to the normal control