Donepezil attenuates vascular dementia in rats through increasing BDNF induced by reducing HDAC6 nuclear translocation

摘要

a The day of BCCAO surgery was regarded as the first day of the experiment. Drugs were administered once a day beginning on d 15. Drug delivery and behavioral tests were performed in the sham group (n = 8), BCCAO model group (n = 12), and donepezil-treated group (n = 12). The MWM test was carried out from days 35 to 41, and the step-down test was carried out from days 43 to 44. All rats were killed on day 45. The significance of the differences in platform escape latency was analyzed by two-way ANOVA. The data are shown as the mean ± SEM. #P < 0.05 and ##P < 0.01, the model group vs the sham group. *P < 0.05 and **P < 0.01, the model + donepezil-treated group vs the model group. b The platform escape latency represented the time for each rat to find the platform in phase II of the MWM test. c The number of platform crossings represented the number of times each rat entered the platform zone in phase III of the MWM test. d The average speed represented the swimming speed of the rats in phase III of the MWM test. e The number of errors was automatically evaluated by the system. An error was counted when a rat on the insulation platform touched the grid and received an electric shock, and the total number of times that the rats received an electric shock in 2 min represented the number of errors. The significance of differences in platform escape latency was analyzed by two-way ANOVA, and the significance of the rest of the data was analyzed by one-way ANOVA. The data are shown as the mean ± SEM. * P < 0.05 and **P < 0.01.