Technical Note: The development of a multi‐physics simulation tool to estimate the background dose by systemic targeted alpha therapy

摘要

To predict biological effects of targeted alpha therapy (TAT) in preclinical studies, dosimetry calculations based on the micro‐level distributions of emitters are essential. Due to the saturation of the tumor antigenic sites and bonding breaks by decay, some of Alpha‐immuno‐conjugate and decay daughters may inevitably be transported by convection and diffusion along with blood or lymphatic circulation. This results in highly nonuniform and unsteady distributions of irradiation sources. Since the micro‐level distribution of emitters cannot be measured and obtained in patients with current technology, a modeling toolset to give more insight of the internal dose could be an alternative.