Apolipoprotein M overexpression through adeno‐associated virus gene transfer improves insulin secretion and insulin sensitivity in Goto‐Kakizaki rats

摘要

The development of type 2 diabetes is a result of insulin resistance in various tissues, including skeletal muscle and liver. Apolipoprotein M (ApoM) plays an important role in the function of high‐density lipoprotein, and also affects hepatic lipid and glucose metabolism. In this study, we aimed to investigate whether ApoM overexpression modulates glucose metabolism and improves insulin sensitivity.