Three platinum-based chemotherapeutic drugs were administered to mice in a cyclic drug administration paradigm at equimolar concentrations. a Cisplatin, carboplatin, and oxaliplatin all contain a central platinum atom. Schematic representation of the experimental protocol including audiometric testing and cyclic drug administration. This figure is adapted from Fernandez et al. . Threshold shift is reported as the difference in ABR thresholds between pre- and post-drug treatment. Mice that received cisplatin (purple) showed significant threshold shifts at 5 of 6 tested frequencies. Hearing thresholds of carboplatin- (blue) and oxaliplatin-treated (orange) mice were not significantly different from those of saline controls (black). Dashed line at 0 dB represents no change in auditory thresholds relative to baseline. OHC function was measured using DPOAEs. Relative to saline-treated control mice (black), cisplatin (purple) caused significantly reduced DPOAE amplitudes at 11 out of 14 tested frequencies. Neither carboplatin nor oxaliplatin caused decreased DPOAE amplitudes at any frequency. Gray shaded region indicates the mean biological noise floor measured during recordings. Noise floor measurements were taken and plotted for each treatment condition. Dashed line at – 5 dB SPL represents system noise level below which DPOAEs are considered absent. All data are presented as group means ± SEM. = 8–10 mice for all groups. * P P F = 116.1, F = 68.19,
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机译：在等摩尔浓度下施用三种基于铂基化学治疗药物在循环药物管理范例中给小鼠施用。顺铂，卡铂和奥沙利铂均含有中央铂原子。实验方案的示意图，包括听力检测和循环药物施用。该图是从Fernandez等人的调整。 。阈值移位被报告为药物前后治疗和药物后阈值的差异。接受顺铂（紫色）的小鼠显示出在6个测试频率的5个中的显着阈值偏移。听力阈值 - （蓝色）和Oxaliplatin处理（橙色）小鼠与盐水管（黑色）的显着不同。在0 dB时的虚线表示相对于基线的听觉阈值没有变化。使用DPOAES测量OHC功能。相对于盐水处理的对照小鼠（黑色），顺铂（紫色）引起14个测试频率中的11种显着减少了DPOAE振幅。卡铂和奥克洛拉汀都没有引起任何频率下降的DPOAE幅度。灰色阴影区域表示录音期间测量的平均生物噪声底板。针对每种治疗条件进行噪声底板测量并绘制。 DASHED LINE AT - 5 DB SPL表示下面的系统噪声水平，DPOAES被认为不存在。所有数据都显示为组表示±SEM。所有组的8-10只小鼠。 * p p f = 116.1，f = 68.19，
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