Synthesis and antiviral activity evaluation of acyclic 2′-azanucleosides bearing a phosphonomethoxy function in the side chain

机译：侧链具有膦酰基甲氧基功能的无环2-氮杂核苷的合成及抗病毒活性评估

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摘要

Acyclic 2 -azanucleosides with a phosphonomethoxy function in the side chain were obtained by coupling of diethyl {2-[ -(pivaloyloxymethyl)- -( -toluenesulfonyl)amino]ethoxymethyl}phosphonate with the pyrimidine nucleobases via the Vorbrüggen-type protocol. The compounds were evaluated in vitro for activity against a broad variety of RNA and DNA viruses.

机译：通过Vorbrüggen-型方案将{2-[-（-新戊酰氧基甲基）-（-甲苯磺酰基）氨基]乙氧基甲基}膦酸二乙酯与嘧啶核苷偶联，获得在侧链具有膦酰基甲氧基功能的无环2-氮杂核苷。在体外评估了这些化合物对各种RNA和DNA病毒的活性。

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期刊名称 Elsevier Public Health Emergency Collection
作者
Mariola Koszytkowska-Stawińska; Erik De Clercq; Jan Balzarini;
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作者单位

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年(卷),期 -1(17),11
年度 -1
页码 -1
总页数 8
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
Azanucleosides; Acyclic nucleoside phosphonates; Nucleoside analogs; Antiviral agents; Sulfonamides;

机译：氮杂核苷;无环核苷膦酸酯;核苷类似物;抗病毒药;磺酰胺;

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专利

1. Synthesis and antiviral activity evaluation of acyclic 2'-azanucleosides bearing a phosphonomethoxy function in the side chain. [J] . Koszytkowska Stawinska M, De Clercq E, Balzarini J Bioorganic and medicinal chemistry . 2009,第11期

机译：侧链具有膦酰基甲氧基功能的无环2'-氮杂核苷的合成和抗病毒活性评估。
2. The synthesis and antiviral properties of acyclic nucleoside analogues with a phosphonomethoxy fragment in the side chain. [J] . Khandazhinskaya A, Yasko M, Shirokova E Current medicinal chemistry . 2006,第24期

机译：侧链具有膦酰基甲氧基片段的无环核苷类似物的合成和抗病毒特性。
3. The Synthesis and Antiviral Properties of Acyclic Nucleoside Analogues with a Phosphonomethoxy Fragment in the Side Chain [J] . A. Khandazhinskaya M. Yasko and E. Shirokova* Current Medicinal Chemistry . 2006,第24期

机译：侧链具有膦氧基甲氧基片段的无环核苷类似物的合成及抗病毒特性
4. EVALUATION OF THE ANTIVIRAL ACTIVITY OF THE PROTOTYPE SYSTEM BOX O_3 EFFICIENCY EVALUATION OF OZONE ON THE HEPATITIS B VIRUS [C] . TREPO D., HABOUZIT S., DUROSELLE P., Ozone world congress . 1995

机译：乙型肝炎病毒对臭氧系统原型系统O_3效率评估的抗病毒活性评估
5. Synthesis, structural analysis and in vitro antiviral activities of novel cyclic and acyclic (S)-HPMPA and (S)-HPMPC tyrosinamide prodrugs [D] . Krylov, Ivan S. 2012

机译：新型环状和非环状（S）-HPMPA和（S）-HPMPC酪氨酸酰胺前药的合成，结构分析和体外抗病毒活性
6. Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure [O] . Rafał Gawin, Erik De Clercq, Lieve Naesens, -1

机译：以磺胺为先导结构开发的无环氮杂核苷的合成及抗病毒评价
7. Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure [O] . Rafał Gawin, Erik De Clercq, Lieve Naesens, 2008

机译：从磺胺胺作为铅结构中氟胺偶核苷的合成与抗病毒评价
8. Synthesis and Reactivity of Cyclotriphosphazenes Bearing Reactive SilaneFunctionalities: Novel Derivatives via Hydrosilylation Reactions [R] . Allcock, H. R., Nelson, C. J., Coggio, W. D. 1991

机译：具有反应性硅烷官能团的环三磷腈的合成和反应性：通过氢化硅烷化反应得到的新型衍生物

Synthesis and antiviral activity evaluation of acyclic 2′-azanucleosides bearing a phosphonomethoxy function in the side chain

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