Identification of C-geranylated flavonoids from Paulownia catalpifolia Gong Tong fruits by HPLC-DAD-ESI-MS/MS and their anti-aging effects on 2BS cells induced by H2O2

摘要

The fruits of Gong Tong are used as a Chinese folk herbal medicine for the treatment of enteritis, tonsillitis, bronchitis, and dysentery, etc. Our previous study has identified new -geranylated flavanones with obvious anti-proliferative effects in lung cancer A549 cells. In the present study, a new -geranylated flavone, paucatalinone C ( ) and five known -geranylated flavanones ( – ) were isolated. In addition, a total of 34 -geranylated flavonoids were detected by HPLC-DAD-ESI-MS/MS coupling techniques from the CH Cl extract of . Futhermore, anti-aging effects of isolated compounds were evaluated with premature senescent 2BS cells induced by H O . Phytochemical results indicated that was a natural resource of abundant -geranylated flavonoids. Diplacone ( ) and paucatalinone A ( ) were the potent anti-aging agents in the premature senescent 2BS cells induced by H O and the C-geranyl substituent may be an important factor because of its lipophilic character.