4-1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl-benzenesulfonic acids: Synthesis antimicrobial activity QSAR studies and antiviral evaluation

摘要

A series of 4-[1-(substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzene sulphonic acids ( ) was synthesized and evaluated, for their antimicrobial activity and the results indicated that compounds 4-[1-(4-Nitrobenzoyl)-1H-benzoimidazol-2-yl]-benzenesulfonic acid ( ) and 4-(1-octadec-9-enoyl-1H-benzoimidazol-2-yl)-benzenesulfonic acid ( ) were found to be the most active ones. QSAR investigations indicated that the multi-target QSAR model was effective in describing the antimicrobial activity over the one-target QSAR models. Further the mt-QSAR model indicated the importance of the topological parameter, Balaban index (J) followed by the electronic parameter, LUMO and topological parameter, valence second order molecular connectivity index ( χ ) in describing the antimicrobial activity of synthesized compounds ( ).