Degradation of Lung Protective Angiotensin Converting Enzyme-2 by Meconium in Human Alveolar Epithelial Cells: A Potential Pathogenic Mechanism in Meconium Aspiration Syndrome

摘要

Nuclear fragmentation in human A549 AECs in response to meconium. Cells exhibiting nuclear fragmentation with propidium iodide (arrowhead) were scored as apoptotic as compared to normal morphologic nuclei (white arrow). Magnification 200 ×. The scale bar is 100 µm. Meconium induces nuclear fragmentation in a dose-dependent manner (2.5–20%). Bars are means ± SE of six observations per treatment. A significant increase in number of apoptotic nuclei as compared to control (C); *  p